Type 2 Innate Lymphocytes are Crucial for Anti-tumour Immunity and Their Adoptive Transfer is an Effective Immunotherapy Against Cancer
hdl:11272/10468
Version: 1 – Released: Wed Mar 29 10:58:33 PDT 2017
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TitleType 2 Innate Lymphocytes are Crucial for Anti-tumour Immunity and Their Adoptive Transfer is an Effective Immunotherapy Against Cancer
Study Global IDhdl:11272/10468
AuthorsSaranchova, Iryna (University of British Columbia, The Michael Smith Laboratories); Han, Jeffrey (University of British Columbia, The Michael Smith Laboratories)
ProducerUniversity of British Columbia (UBC), The Michael Smith Laboratories
Production PlaceVancouver, BC
Software FlowJo, 8.7
Funding AgencyCIHR, Austrian Academy of Sciences
DistributorUniversity of British Columbia (UBC)
ContactWilfred Jefferies (University of British Columbia), wilf@msl.ubc.ca
DepositorCheryl Pfeifer
Deposit DateMarch 29, 2017
Version1, March 29, 2017
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Description

Type 2 innate lymphoid cells (ILC2) potentiate adaptive immune responses however whether they have a role in mediating cancer immunity has not been assessed. Here, we report that mice genetically lacking ILC2s have significantly increased tumour growth rates and higher frequency of circulating tumour cells (CTCs) and metastasis to distal organs. Our data supports the conclusions that tumour-infiltrating ILC2s help mediate tumour immune-surveillance by promoting adaptive T cells responses and that ILC2s play a hitherto undescribed role in controlling metastasis. Furthermore, we demonstrate that adoptive transfer of ILC2s mediates a dramatic regression in cancer growth. Therefore, the adoptive transfer of ILC2s provides a new immunotherapeutic approach with the potential to aid in the eradication of cancers.

Description DateMarch 29, 2017
KeywordsType 2 Innate Lymphocyte,; ILC2; Anti-tumour Immunity; Metastasis; Adoptive Transfer
Topic ClassificationOpen (Open Access Tag)
Related MaterialThis is the link for citing the paper
Country/NationCanada (CA), United States (US)
Data Availability
Availability StatusEmbargoed until paper publication
Size of Collection4
Number of Files 4
Terms of Use
RestrictionsCreative Commons Licence
This work is licensed under a Creative Commons Attribution 4.0 International License.
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"Type 2 Innate Lymphocytes are Crucial for Anti-tumour Immunity and Their Adoptive Transfer is an Effective Immunotherapy Against Cancer", hdl:11272/10468