Research data from the University of British Columbia Michael Smith Laboratories
Dr. Wilfred Jefferies
Dr. Wilfred Jefferies Research Data Repositories
Sort By:
Studies: 1 | Downloads: 0
Description:

Type 2 innate lymphoid cells (ILC2) potentiate adaptive immune responses however whether they have a role in mediating cancer immunity has not been assessed. Here, we report that mice genetically lacking ILC2s have significantly increased tumour growth rates and higher frequency of circulating tumour cells (CTCs) and metastasis to distal organs. Our data supports the conclusions that tumour-infiltrating ILC2s help mediate tumour immune-surveillance by promoting adaptive T cells responses and that ILC2s play a hitherto undescribed role in controlling metastasis. Furthermore, we demonstrate that adoptive transfer of ILC2s mediates a dramatic regression in cancer growth. Therefore, the adoptive transfer of ILC2s provides a new immunotherapeutic approach with the potential to aid in the eradication of cancers.

Related Material:This is the link for citing the paper
hdl:11272/10468
0 downloads
Last Released: Mar 29, 2017
Abacus Dataverse Network - British Columbia Research Library Data Services - Hosted at the University of British Columbia © 2017